Protein-coding gene in the species Homo sapiens
| H1-8 |
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| Identifiers |
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| Aliases | H1-8, osH1, H1.8, H1oo, H1 histone family member O, oocyte specific, H1 histone family member O oocyte specific, H1.8 linker histone, H1FOO |
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| External IDs | MGI: 2176207; HomoloGene: 51377; GeneCards: H1-8; OMA:H1-8 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 3 (human)[1] |
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| | Band | 3q22.1 | Start | 129,543,175 bp[1] |
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| End | 129,551,467 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 6 (mouse)[2] |
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| | Band | 6|6 E3 | Start | 115,921,899 bp[2] |
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| End | 115,927,197 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - oocyte
- secondary oocyte
- left testis
- right testis
- gonad
- mucosa of nose
- human musculoskeletal system
- anterior pituitary
- olfactory zone of nasal mucosa
- muscular system
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| | Top expressed in | - zygote
- secondary oocyte
- primary oocyte
- cardiac muscle tissue of left ventricle
- extensor digitorum longus muscle
- interventricular septum
- plantaris muscle
- embryo
- cingulate gyrus
- morula
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - DNA binding
- nucleosomal DNA binding
- double-stranded DNA binding
- protein binding
| | Cellular component | - cytoplasm
- nucleosome
- extracellular exosome
- nucleolus
- nucleus
- chromosome
- female germ cell nucleus
| | Biological process | - nucleosome assembly
- meiosis
- regulation of DNA methylation
- negative regulation of stem cell differentiation
- regulation of transcription, DNA-templated
- chromosome condensation
- negative regulation of DNA recombination
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 3: 129.54 – 129.55 Mb | Chr 6: 115.92 – 115.93 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Histone H1oo is a protein that in humans is encoded by the H1FOO gene.[5][6]
Function
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The protein encoded is a member of the histone H1 family. The related mouse gene is expressed only in oocytes.[6]
It incorporates into sperm chromatin after fertilisation.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000178804 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042279 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (November 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
- ^ a b "Entrez Gene: H1 histone family".
- ^ Mizusawa Y, Kuji N, Tanaka Y, et al. (March 2010). "Expression of human oocyte-specific linker histone protein and its incorporation into sperm chromatin during fertilization". Fertil Steril. 93 (4): 1134–1141. doi:10.1016/j.fertnstert.2008.11.028. PMID 19147139.
Further reading
- Teranishi T, Tanaka M, Kimoto S, et al. (2004). "Rapid replacement of somatic linker histones with the oocyte-specific linker histone H1foo in nuclear transfer". Dev. Biol. 266 (1): 76–86. doi:10.1016/j.ydbio.2003.10.004. PMID 14729479.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Tanaka Y, Kato S, Tanaka M, et al. (2003). "Structure and expression of the human oocyte-specific histone H1 gene elucidated by direct RT-nested PCR of a single oocyte". Biochem. Biophys. Res. Commun. 304 (2): 351–7. doi:10.1016/S0006-291X(03)00610-7. PMID 12711322.
- Tanaka M, Kihara M, Hennebold JD, et al. (2005). "H1FOO is coupled to the initiation of oocytic growth". Biol. Reprod. 72 (1): 135–42. doi:10.1095/biolreprod.104.032474. PMID 15371275.
- Gao S, Chung YG, Parseghian MH, et al. (2004). "Rapid H1 linker histone transitions following fertilization or somatic cell nuclear transfer: evidence for a uniform developmental program in mice". Dev. Biol. 266 (1): 62–75. doi:10.1016/j.ydbio.2003.10.003. PMID 14729478.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
