Grancalcin

Protein found in humans
GCA
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1F4O, 1F4Q, 1K94, 1K95

Identifiers
AliasesGCA, GCL, grancalcin
External IDsOMIM: 607030; MGI: 1918521; HomoloGene: 22702; GeneCards: GCA; OMA:GCA - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for GCA
Genomic location for GCA
Band2q24.2Start162,318,840 bp[1]
End162,371,595 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for GCA
Genomic location for GCA
Band2|2 C1.3Start62,494,629 bp[2]
End62,524,453 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • blood

  • bone marrow

  • bone marrow cells

  • trabecular bone

  • granulocyte

  • spleen

  • germinal epithelium

  • C1 segment

  • right lung
Top expressed in
  • granulocyte

  • lumbar spinal ganglion

  • morula

  • pineal gland

  • primary motor cortex

  • olfactory epithelium

  • seminal vesicula

  • sciatic nerve

  • ventricular zone

  • retinal pigment epithelium
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • protein homodimerization activity
  • metal ion binding
  • calcium-dependent cysteine-type endopeptidase activity
  • protein heterodimerization activity
  • calcium ion binding
Cellular component
  • plasma membrane
  • extracellular exosome
  • membrane
  • extracellular region
  • cytosol
  • azurophil granule lumen
  • cytoplasm
Biological process
  • membrane fusion
  • proteolysis
  • neutrophil degranulation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

25801

227960

Ensembl

ENSG00000115271

ENSMUSG00000026893

UniProt

P28676

Q8VC88

RefSeq (mRNA)
NM_012198
NM_001330265
NM_001330266
NM_001330267
NM_001330268

NM_001330270
NM_001330271

NM_145523

RefSeq (protein)
NP_001317194
NP_001317195
NP_001317196
NP_001317197
NP_001317199

NP_001317200
NP_036330

NP_663498

Location (UCSC)Chr 2: 162.32 – 162.37 MbChr 2: 62.49 – 62.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Grancalcin is a protein that in humans is encoded by the GCA gene.[5][6][7][8]

This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.[8]

Interactions

GCA (gene) has been shown to interact with SRI.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115271 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026893 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Boyhan A, Casimir CM, French JK, Teahan CG, Segal AW (Mar 1992). "Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes". J Biol Chem. 267 (5): 2928–33. doi:10.1016/S0021-9258(19)50675-5. PMID 1737748.
  6. ^ Teahan CG, Totty NF, Segal AW (Oct 1992). "Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils". Biochem J. 286. ( Pt 2) (2): 549–54. doi:10.1042/bj2860549. PMC 1132932. PMID 1530588.
  7. ^ a b Hansen C, Tarabykina S, la Cour JM, Lollike K, Berchtold MW (Jun 2003). "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro". FEBS Lett. 545 (2–3): 151–4. doi:10.1016/S0014-5793(03)00518-0. PMID 12804766. S2CID 42572647.
  8. ^ a b "Entrez Gene: GCA grancalcin, EF-hand calcium binding protein".

Further reading

  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Jia J, Borregaard N, Lollike K, Cygler M (2002). "Structure of Ca(2+)-loaded human grancalcin". Acta Crystallogr. D. 57 (Pt 12): 1843–9. doi:10.1107/S0907444901016511. PMID 11717497.
  • Lollike K, Johnsen AH, Durussel I, et al. (2001). "Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner". J. Biol. Chem. 276 (21): 17762–9. doi:10.1074/jbc.M100965200. PMID 11279160.
  • Jia J, Han Q, Borregaard N, et al. (2000). "Crystal structure of human grancalcin, a member of the penta-EF-hand protein family". J. Mol. Biol. 300 (5): 1271–81. doi:10.1006/jmbi.2000.3925. PMID 10903868.
  • Maki M, Narayana SV, Hitomi K (1998). "A growing family of the Ca2+-binding proteins with five EF-hand motifs". Biochem. J. 328. ( Pt 2) (Pt 2): 718–20. PMC 1218977. PMID 9441591.
  • v
  • t
  • e
  • 1f4o: CRYSTAL STRUCTURE OF GRANCALCIN WITH BOUND CALCIUM
    1f4o: CRYSTAL STRUCTURE OF GRANCALCIN WITH BOUND CALCIUM
  • 1f4q: CRYSTAL STRUCTURE OF APO GRANCALCIN
    1f4q: CRYSTAL STRUCTURE OF APO GRANCALCIN
  • 1k94: Crystal structure of des(1-52)grancalcin with bound calcium
    1k94: Crystal structure of des(1-52)grancalcin with bound calcium
  • 1k95: Crystal structure of des(1-52)grancalcin with bound calcium
    1k95: Crystal structure of des(1-52)grancalcin with bound calcium


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