Protein-coding gene in the species Homo sapiens
GSTT1 |
---|
![](//upload.wikimedia.org/wikipedia/commons/thumb/2/2b/Protein_GSTT1_PDB_2c3n.png/250px-Protein_GSTT1_PDB_2c3n.png) |
Available structures |
---|
PDB | Human UniProt search: PDBe RCSB |
---|
List of PDB id codes |
---|
2C3N, 2C3Q, 2C3T |
|
|
Identifiers |
---|
Aliases | GSTT1, glutathione S-transferase theta 1 |
---|
External IDs | OMIM: 600436; GeneCards: GSTT1; OMA:GSTT1 - orthologs |
---|
Gene location (Human) |
---|
![Chromosome 22 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/6/62/Ideogram_human_chromosome_22.svg/300px-Ideogram_human_chromosome_22.svg.png) | Chr. | Chromosome 22 (human) |
---|
| Band | 22q11.23 | Start | 24,376,133 bp |
---|
End | 24,384,680 bp |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - vena cava
- thoracic diaphragm
- adrenal gland
- external globus pallidus
- jejunal mucosa
- right ventricle
- coronary artery
- Skeletal muscle tissue of rectus abdominis
- lateral nuclear group of thalamus
- cingulate gyrus
|
| | More reference expression data |
|
---|
BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/a/a9/PBB_GE_GSTT1_203815_at_fs.png/250px-PBB_GE_GSTT1_203815_at_fs.png) | More reference expression data |
|
---|
|
Gene ontology |
---|
Molecular function | - transferase activity
- glutathione peroxidase activity
- glutathione transferase activity
- protein binding
| Cellular component | - cytoplasm
- cytosol
- extracellular exosome
| Biological process | - glutathione derivative biosynthetic process
- glutathione metabolic process
- cellular oxidant detoxification
| Sources:Amigo / QuickGO |
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | NM_000853 NM_001293807 NM_001293808 NM_001293809 NM_001293810
|
---|
NM_001293811 NM_001293812 NM_001293813 NM_001293814 |
| |
---|
RefSeq (protein) | NP_000844 NP_001280736 NP_001280737 NP_001280738 NP_001280739
|
---|
NP_001280740 NP_001280741 NP_001280742 NP_001280743 |
| |
---|
Location (UCSC) | Chr 22: 24.38 – 24.38 Mb | n/a |
---|
PubMed search | [1] | n/a |
---|
|
Wikidata |
|
Glutathione S-transferase theta-1 is an enzyme that in humans is encoded by the GSTT1 gene.[2]
Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.[3]
References
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Webb G, Vaska V, Coggan M, Board P (Jun 1996). "Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1)". Genomics. 33 (1): 121–3. doi:10.1006/geno.1996.0167. PMID 8617495.
- ^ "Entrez Gene: GSTT1 glutathione S-transferase theta 1".
PDB gallery
-
2c3n: HUMAN GLUTATHIONE-S-TRANSFERASE T1-1, APO FORM -
2c3q: HUMAN GLUTATHIONE-S-TRANSFERASE T1-1 W234R MUTANT, COMPLEX WITH S-HEXYLGLUTATHIONE -
2c3t: HUMAN GLUTATHIONE-S-TRANSFERASE T1-1, W234R MUTANT, APO FORM |
![Stub icon](//upload.wikimedia.org/wikipedia/commons/thumb/6/61/DNA_stub.png/40px-DNA_stub.png) | This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it. |