NOP53 |
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Identifiers |
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Aliases | NOP53, PICT-1, PICT1, GLTSCR2, glioma tumor suppressor candidate region gene 2, NOP53 ribosome biogenesis factor |
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External IDs | OMIM: 605691; MGI: 2154441; HomoloGene: 44130; GeneCards: NOP53; OMA:NOP53 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 19 (human)[1] |
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| Band | 19q13.33 | Start | 47,745,546 bp[1] |
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End | 47,757,058 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 7 (mouse)[2] |
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| Band | 7 8.64 cM|7 A2 | Start | 15,670,108 bp[2] |
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End | 15,679,999 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - left ovary
- body of pancreas
- right ovary
- skin of arm
- skin of leg
- ganglionic eminence
- skin of abdomen
- canal of the cervix
- body of uterus
- right uterine tube
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| Top expressed in | - neural layer of retina
- ventricular zone
- yolk sac
- lip
- transitional epithelium of urinary bladder
- muscle of thigh
- esophagus
- genital tubercle
- molar
- granulocyte
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - RNA binding
- 5S rRNA binding
- protein binding
- p53 binding
- identical protein binding
| Cellular component | - intracellular anatomical structure
- intracellular membrane-bounded organelle
- nucleus
- nucleolus
- cytosol
- fibrillar center
- rDNA heterochromatin
- nucleoplasm
| Biological process | - ribosomal large subunit assembly
- regulation of protein phosphorylation
- protein stabilization
- regulation of signal transduction by p53 class mediator
- negative regulation of signal transduction by p53 class mediator
- regulation of aerobic respiration
- ribosomal large subunit export from nucleus
- negative regulation of transcription by RNA polymerase II
- DNA repair
- mitotic G2 DNA damage checkpoint signaling
- negative regulation of phosphatidylinositol 3-kinase signaling
- negative regulation of protein-containing complex assembly
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- regulation of apoptotic process
- regulation of cell cycle
- cellular response to hypoxia
- protein localization to nucleolus
- protein localization to nucleoplasm
- cellular response to DNA damage stimulus
- regulation of RIG-I signaling pathway
- negative regulation of protein kinase B signaling
- negative regulation of transcription of nucleolar large rRNA by RNA polymerase I
- positive regulation of protein K63-linked deubiquitination
- ribosome biogenesis
- rRNA processing
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 19: 47.75 – 47.76 Mb | Chr 7: 15.67 – 15.68 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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