GCAT

Protein-coding gene in the species Homo sapiens
GCAT
Identifiers
AliasesGCAT, KBL, glycine C-acetyltransferase
External IDsOMIM: 607422; MGI: 1349389; HomoloGene: 8475; GeneCards: GCAT; OMA:GCAT - orthologs
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • right lobe of liver

  • left ventricle

  • oocyte

  • endothelial cell

  • prefrontal cortex

  • Brodmann area 9

  • amygdala

  • nucleus accumbens

  • cingulate gyrus
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • glycine C-acetyltransferase activity
  • transferase activity
  • pyridoxal phosphate binding
  • acyltransferase activity
  • catalytic activity
Cellular component
  • mitochondrion
  • nucleus
  • nucleoplasm
  • nuclear speck
  • mitochondrial inner membrane
Biological process
  • cellular amino acid metabolic process
  • metabolism
  • biosynthesis
  • threonine catabolic process
  • L-threonine catabolic process to glycine
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23464

26912

Ensembl

n/a

ENSMUSG00000006378

UniProt

O75600

O88986

RefSeq (mRNA)

NM_001171690
NM_014291

NM_001161712
NM_013847

RefSeq (protein)

NP_001165161
NP_055106

NP_001155184
NP_038875

Location (UCSC)n/an/a
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

Glycine C-acetyltransferase is a protein that in humans is encoded by the GCAT gene.[3]

Function

The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14.

References

  1. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: Glycine C-acetyltransferase".

Further reading

  • Jacquot C, Lanco X, Carbonnelle D, Sevestre O, Tomasoni C, Briad G, Juget M, Roussis V, Roussakis C (2002). "Effect of four genes (ALDH1, NRF1, JAM and KBL) on proliferation arrest in a non-small cell bronchopulmonary cancer line". Anticancer Research. 22 (4): 2229–35. PMID 12174908.
  • Tressel T, Thompson R, Zieske LR, Menendez MI, Davis L (Dec 1986). "Interaction between L-threonine dehydrogenase and aminoacetone synthetase and mechanism of aminoacetone production". The Journal of Biological Chemistry. 261 (35): 16428–37. doi:10.1016/S0021-9258(18)66584-6. PMID 3536927.
  • Edgar AJ, Polak JM (Mar 2000). "Molecular cloning of the human and murine 2-amino-3-ketobutyrate coenzyme A ligase cDNAs". European Journal of Biochemistry. 267 (6): 1805–12. doi:10.1046/j.1432-1327.2000.01175.x. PMID 10712613.
  • Hashizume O, Ohnishi S, Mito T, Shimizu A, Ishikawa K, Nakada K, Soda M, Mano H, Togayachi S, Miyoshi H, Okita K, Hayashi J (2015). "Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects". Scientific Reports. 5 (10434): 10434. Bibcode:2015NatSR...510434H. doi:10.1038/srep10434. PMC 5377050. PMID 26000717.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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