FLVCR1

Protein-coding gene in the species Homo sapiens
FLVCR1
Identifiers
AliasesFLVCR1, AXPC1, FLVCR, MFSD7B, PCA, PCARP, feline leukemia virus subgroup C cellular receptor 1, SLC49A1, FLVCR heme transporter 1
External IDsOMIM: 609144; MGI: 2444881; HomoloGene: 56661; GeneCards: FLVCR1; OMA:FLVCR1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for FLVCR1
Genomic location for FLVCR1
Band1q32.3Start212,858,275 bp[1]
End212,899,363 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for FLVCR1
Genomic location for FLVCR1
Band1|1 H6Start190,738,044 bp[2]
End190,758,355 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • jejunal mucosa

  • mucosa of ileum

  • pancreatic epithelial cell

  • corpus epididymis

  • bronchial epithelial cell

  • buccal mucosa cell

  • duodenum

  • germinal epithelium

  • pylorus

  • retinal pigment epithelium
Top expressed in
  • epithelium of small intestine

  • ciliary body

  • temporal muscle

  • migratory enteric neural crest cell

  • granulocyte

  • triceps brachii muscle

  • intercostal muscle

  • ileum

  • digastric muscle

  • stroma of bone marrow
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • transporter activity
  • protein binding
  • heme transmembrane transporter activity
  • heme binding
Cellular component
  • integral component of membrane
  • mitochondrial membranes
  • membrane
  • plasma membrane
  • integral component of plasma membrane
  • mitochondrion
Biological process
  • embryonic skeletal system morphogenesis
  • head morphogenesis
  • limb morphogenesis
  • multicellular organism growth
  • embryonic digit morphogenesis
  • in utero embryonic development
  • mitochondrial transport
  • spleen development
  • heme transport
  • multicellular organism development
  • blood vessel development
  • erythrocyte differentiation
  • regulation of organ growth
  • heme export
  • cellular iron ion homeostasis
  • erythrocyte maturation
  • transmembrane transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

28982

226844

Ensembl

ENSG00000162769

ENSMUSG00000066595

UniProt

Q9Y5Y0

B2RXV4

RefSeq (mRNA)

NM_014053

NM_001081259
NM_001313747
NM_198025

RefSeq (protein)

NP_054772

NP_001074728
NP_001300676
NP_932142

Location (UCSC)Chr 1: 212.86 – 212.9 MbChr 1: 190.74 – 190.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Feline leukemia virus subgroup C receptor-related protein 1 is a protein that in humans is encoded by the FLVCR1 gene (SLC49A1).[5][6][7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162769 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066595 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tailor CS, Willett BJ, Kabat D (1999). "A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily". J. Virol. 73 (8): 6500–5. doi:10.1128/JVI.73.8.6500-6505.1999. PMC 112732. PMID 10400745.
  6. ^ Quigley JG, Burns CC, Anderson MM, Lynch ED, Sabo KM, Overbaugh J, Abkowitz JL (2000). "Cloning of the cellular receptor for feline leukemia virus subgroup C (FeLV-C), a retrovirus that induces red cell aplasia". Blood. 95 (3): 1093–9. doi:10.1182/blood.V95.3.1093.003k01_1093_1099. PMID 10648427.
  7. ^ "Entrez Gene: FLVCR feline leukemia virus subgroup C cellular receptor".
  8. ^ Crielaard, Bart J.; Lammers, Twan; Rivella, Stefano (2017-02-03). "Targeting iron metabolism in drug discovery and delivery". Nature Reviews Drug Discovery. advance online publication (6): 400–423. doi:10.1038/nrd.2016.248. ISSN 1474-1784. PMC 5455971. PMID 28154410.

Further reading

  • Lipovich L, Hughes AL, King MC, Abkowitz JL, Quigley JG (2002). "Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus". Gene. 286 (2): 203–13. doi:10.1016/S0378-1119(02)00457-2. PMID 11943475.
  • Quigley JG, Yang Z, Worthington MT, Phillips JD, Sabo KM, Sabath DE, Berg CL, Sassa S, Wood BL, Abkowitz JL (2004). "Identification of a human heme exporter that is essential for erythropoiesis". Cell. 118 (6): 757–66. doi:10.1016/j.cell.2004.08.014. PMID 15369674. S2CID 12749187.
  • Quigley JG, Gazda H, Yang Z, Ball S, Sieff CA, Abkowitz JL (2006). "Investigation of a putative role for FLVCR, a cytoplasmic heme exporter, in Diamond-Blackfan anemia". Blood Cells Mol. Dis. 35 (2): 189–92. doi:10.1016/j.bcmd.2005.01.005. PMID 15996880.
  • Brown JK, Fung C, Tailor CS (2006). "Comprehensive mapping of receptor-functioning domains in feline leukemia virus subgroup C receptor FLVCR1". J. Virol. 80 (4): 1742–51. doi:10.1128/JVI.80.4.1742-1751.2006. PMC 1367145. PMID 16439531.


  • v
  • t
  • e