Protein-coding gene in the species Homo sapiens
FLRT1 |
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Identifiers |
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Aliases | FLRT1, SPG68, fibronectin leucine rich transmembrane protein 1 |
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External IDs | OMIM: 604806; MGI: 3026647; HomoloGene: 40864; GeneCards: FLRT1; OMA:FLRT1 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 11 (human)[1] |
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| Band | 11q13.1 | Start | 64,035,931 bp[1] |
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End | 64,119,173 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 19 (mouse)[2] |
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| Band | 19|19 A | Start | 7,069,366 bp[2] |
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End | 7,083,094 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - Brodmann area 10
- frontal pole
- buccal mucosa cell
- paraflocculus of cerebellum
- ventral tegmental area
- inferior ganglion of vagus nerve
- cerebellar vermis
- thalamus
- globus pallidus
- internal globus pallidus
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| Top expressed in | - olfactory epithelium
- olfactory tubercle
- medial dorsal nucleus
- otolith organ
- utricle
- cingulate gyrus
- primary motor cortex
- human kidney
- lumbar subsegment of spinal cord
- globus pallidus
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - protein-macromolecule adaptor activity
- fibroblast growth factor receptor binding
- protein kinase inhibitor activity
| Cellular component | - cytoplasm
- integral component of membrane
- cell projection
- endoplasmic reticulum membrane
- membrane
- cell-cell junction
- focal adhesion
- integral component of plasma membrane
- neuronal cell body membrane
- extracellular region
- cell junction
- endoplasmic reticulum
- perinuclear region of cytoplasm
- neuron projection terminus
- cytoplasmic vesicle membrane
- cytoplasmic vesicle
- plasma membrane
- extracellular space
- extracellular matrix
| Biological process | - negative regulation of protein kinase activity
- cytokine-mediated signaling pathway
- dendrite development
- neuron projection extension
- multicellular organism development
- cell adhesion
- negative regulation of receptor signaling pathway via JAK-STAT
- positive regulation of synapse assembly
- fibroblast growth factor receptor signaling pathway
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 11: 64.04 – 64.12 Mb | Chr 19: 7.07 – 7.08 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Fibronectin leucine rich transmembrane protein 1 is a protein that in humans is encoded by the FLRT1 gene. [5]
Function
This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in the kidney and brain.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000126500 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047787 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Fibronectin leucine rich transmembrane protein 1". Retrieved 2017-05-30.
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.