FBP1

Protein-coding gene in the species Homo sapiens
FBP1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1FTA, 2FHY, 2FIE, 2FIX, 2JJK, 2VT5, 2WBB, 2WBD, 2Y5K, 2Y5L, 3A29, 3KBZ, 3KC0, 3KC1, 4MJO

Identifiers
AliasesFBP1, FBP, fructose-bisphosphatase 1
External IDsOMIM: 611570; MGI: 95492; HomoloGene: 55467; GeneCards: FBP1; OMA:FBP1 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for FBP1
Genomic location for FBP1
Band9q22.32Start94,603,133 bp[1]
End94,640,249 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for FBP1
Genomic location for FBP1
Band13|13 B3Start63,012,567 bp[2]
End63,036,096 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • jejunal mucosa

  • mucosa of ileum

  • duodenum

  • human kidney

  • right lung

  • upper lobe of left lung

  • kidney tubule

  • monocyte

  • mucosa of transverse colon
Top expressed in
  • left lobe of liver

  • right kidney

  • human kidney

  • seminiferous tubule

  • gallbladder

  • spermatocyte

  • spermatid

  • proximal tubule

  • epithelium of small intestine

  • Ileal epithelium
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • metal ion binding
  • phosphoric ester hydrolase activity
  • identical protein binding
  • hydrolase activity
  • catalytic activity
  • monosaccharide binding
  • AMP binding
  • phosphatase activity
  • fructose 1,6-bisphosphate 1-phosphatase activity
Cellular component
  • cytoplasm
  • extracellular exosome
  • cytosol
  • nucleus
Biological process
  • fructose metabolic process
  • fructose 6-phosphate metabolic process
  • cellular response to magnesium ion
  • metabolism
  • dephosphorylation
  • regulation of gluconeogenesis
  • negative regulation of cell growth
  • protein homotetramerization
  • negative regulation of Ras protein signal transduction
  • gluconeogenesis
  • sucrose biosynthetic process
  • fructose 1,6-bisphosphate metabolic process
  • carbohydrate metabolic process
  • negative regulation of transcription by RNA polymerase II
  • negative regulation of glycolytic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2203

14121

Ensembl

ENSG00000165140

ENSMUSG00000069805

UniProt

P09467

Q9QXD6

RefSeq (mRNA)

NM_000507
NM_001127628

NM_019395

RefSeq (protein)

NP_000498
NP_001121100

NP_062268

Location (UCSC)Chr 9: 94.6 – 94.64 MbChr 13: 63.01 – 63.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fructose-1,6-bisphosphatase 1 is a protein that in humans is encoded by the FBP1 gene.[5]

Function

Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165140 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069805 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Fructose-1,6-bisphosphatase 1". Retrieved 2014-04-19.

Further reading

  • Yáñez AJ, Bertinat R, Spichiger C, Carcamo JG, de Los Angeles García M, Concha II, Nualart F, Slebe JC (Oct 2005). "Novel expression of liver FBPase in Langerhans islets of human and rat pancreas". Journal of Cellular Physiology. 205 (1): 19–24. doi:10.1002/jcp.20407. hdl:10533/176131. PMID 15965961. S2CID 40822845.
  • Faiyaz-Ul-Haque M, Al-Owain M, Al-Dayel F, Al-Hassnan Z, Al-Zaidan H, Rahbeeni Z, Al-Sayed M, Balobaid A, Cluntun A, Toulimat M, Abalkhail H, Peltekova I, Zaidi SH (Dec 2009). "Novel FBP1 gene mutations in Arab patients with fructose-1,6-bisphosphatase deficiency". European Journal of Pediatrics. 168 (12): 1467–71. doi:10.1007/s00431-009-0953-9. PMID 19259699. S2CID 23777808.
  • Kikawa Y, Inuzuka M, Takano T, Shigematsu Y, Nakai A, Yamamoto Y, Jin BY, Koga J, Taketo A, Sudo M (Mar 1994). "cDNA sequences encoding human fructose 1,6-bisphosphatase from monocytes, liver and kidney: application of monocytes to molecular analysis of human fructose 1,6-bisphosphatase deficiency". Biochemical and Biophysical Research Communications. 199 (2): 687–93. doi:10.1006/bbrc.1994.1283. PMID 8135811.
  • Besançon F, Just J, Bourgeade MF, Van Weyenbergh J, Solomon D, Guillozo H, Wietzerbin J, Cayre YE (Aug 1997). "HIV-1 p17 and IFN-gamma both induce fructose 1,6-bisphosphatase". Journal of Interferon & Cytokine Research. 17 (8): 461–7. doi:10.1089/jir.1997.17.461. PMID 9282826.
  • Gizak A, Maciaszczyk-Dziubinska E, Jurowicz M, Rakus D (Nov 2009). "Muscle FBPase is targeted to nucleus by its 203KKKGK207 sequence". Proteins. 77 (2): 262–7. doi:10.1002/prot.22506. PMID 19626708. S2CID 22934928.
  • Zhang Y, Liang JY, Huang S, Ke H, Lipscomb WN (Feb 1993). "Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase". Biochemistry. 32 (7): 1844–57. doi:10.1021/bi00058a019. PMID 8382525.
  • Visinoni S, Khalid NF, Joannides CN, Shulkes A, Yim M, Whitehead J, Tiganis T, Lamont BJ, Favaloro JM, Proietto J, Andrikopoulos S, Fam BC (May 2012). "The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity". Diabetes. 61 (5): 1122–32. doi:10.2337/db11-1511. PMC 3331739. PMID 22517657.
  • Liu X, Wang X, Zhang J, Lam EK, Shin VY, Cheng AS, Yu J, Chan FK, Sung JJ, Jin HC (Jan 2010). "Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis". Oncogene. 29 (3): 442–50. doi:10.1038/onc.2009.332. PMID 19881551.
  • Kikawa Y, Inuzuka M, Jin BY, Kaji S, Koga J, Yamamoto Y, Fujisawa K, Hata I, Nakai A, Shigematsu Y, Mizunuma H, Taketo A, Mayumi M, Sudo M (Oct 1997). "Identification of genetic mutations in Japanese patients with fructose-1,6-bisphosphatase deficiency". American Journal of Human Genetics. 61 (4): 852–61. doi:10.1086/514875. PMC 1715983. PMID 9382095.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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