Enkurin

Protein-coding gene in the species Homo sapiens
ENKUR
Identifiers
AliasesENKUR, C10orf63, CFAP106, enkurin, TRPC channel interacting protein
External IDsOMIM: 611025; MGI: 1918483; HomoloGene: 17022; GeneCards: ENKUR; OMA:ENKUR - orthologs
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[1]
Chromosome 2 (mouse)
Genomic location for ENKUR
Genomic location for ENKUR
Band2|2 A3Start21,185,542 bp[1]
End21,210,176 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bronchial epithelial cell

  • right uterine tube

  • monocyte

  • bone marrow cells

  • hypothalamus

  • caudate nucleus

  • ganglionic eminence

  • putamen

  • nucleus accumbens

  • amygdala
Top expressed in
  • seminiferous tubule

  • olfactory epithelium

  • otolith organ

  • utricle

  • spermatid

  • vestibular sensory epithelium

  • spermatocyte

  • right lung lobe

  • median eminence

  • Epithelium of choroid plexus
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

219670

71233

Ensembl

n/a

ENSMUSG00000026679

UniProt

Q8TC29

Q6SP97

RefSeq (mRNA)

NM_001270383
NM_145010

NM_027728

RefSeq (protein)

NP_001257312
NP_659447

NP_082004

Location (UCSC)n/aChr 2: 21.19 – 21.21 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Enkurin is a protein that in humans is encoded by the ENKUR gene.[4][5]

Enkurin interacts with transient receptor potential canonical (TRPC) cation channels (e.g., TRPC1) and functions as an adaptor protein, tethering signal transduction proteins to TRPC channels.[5]

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026679 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Entrez Gene: enkurin".
  5. ^ a b Sutton KA, Jungnickel MK, Wang Y, Cullen K, Lambert S, Florman HM (October 2004). "Enkurin is a novel calmodulin and TRPC channel binding protein in sperm". Dev. Biol. 274 (2): 426–35. doi:10.1016/j.ydbio.2004.07.031. PMID 15385169.

Further reading

  • Beech DJ (2007). "Canonical transient receptor potential". Transient Receptor Potential (TRP) Channels. Handbook of Experimental Pharmacology. Vol. 179. pp. 109–23. doi:10.1007/978-3-540-34891-7_6. ISBN 978-3-540-34889-4. PMID 17217053.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.


  • v
  • t
  • e