EPS8L3

Protein-coding gene in the species Homo sapiens
EPS8L3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1WXT

Identifiers
AliasesEPS8L3, EPS8R3, EPS8 like 3, HYPT5
External IDsOMIM: 614989; MGI: 2139743; HomoloGene: 15878; GeneCards: EPS8L3; OMA:EPS8L3 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for EPS8L3
Genomic location for EPS8L3
Band1p13.3Start109,750,080 bp[1]
End109,764,027 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for EPS8L3
Genomic location for EPS8L3
Band3|3 F2.3Start107,784,545 bp[2]
End107,800,216 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • rectum

  • mucosa of ileum

  • gallbladder

  • jejunal mucosa

  • duodenum

  • mucosa of sigmoid colon

  • gastric mucosa

  • pancreatic ductal cell

  • testicle
Top expressed in
  • intestinal villus

  • ileum

  • duodenum

  • epithelium of small intestine

  • large intestine

  • colon

  • jejunum

  • left colon

  • crypt of lieberkuhn of small intestine

  • zygote
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • actin filament binding
  • actin binding
Cellular component
  • cytoplasm
  • plasma membrane
  • ruffle membrane
Biological process
  • regulation of hair cycle
  • Rho protein signal transduction
  • regulation of Rho protein signal transduction
  • positive regulation of ruffle assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79574

99662

Ensembl

ENSG00000198758

ENSMUSG00000040600

UniProt

Q8TE67

Q91WL0

RefSeq (mRNA)

NM_024526
NM_133181
NM_139053
NM_001319952

NM_133867

RefSeq (protein)

NP_001306881
NP_078802
NP_573444
NP_620641

NP_598628

Location (UCSC)Chr 1: 109.75 – 109.76 MbChr 3: 107.78 – 107.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Epidermal growth factor receptor kinase substrate 8-like protein 3 is an enzyme that in humans is encoded by the EPS8L3 gene.[5][6]

This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. Alternatively spliced transcript variants encoding different isoforms exist.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198758 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040600 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tocchetti A, Confalonieri S, Scita G, Di Fiore PP, Betsholtz C (Mar 2003). "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure". Genomics. 81 (2): 234–44. doi:10.1016/S0888-7543(03)00002-8. PMID 12620401.
  6. ^ a b "Entrez Gene: EPS8L3 EPS8-like 3".

Further reading

  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Offenhäuser N, Borgonovo A, Disanza A, et al. (2004). "The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway". Mol. Biol. Cell. 15 (1): 91–8. doi:10.1091/mbc.E03-06-0427. PMC 307530. PMID 14565974.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
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  • 1wxt: Solution structure of the SH3 domain of human hypothetical protein FLJ21522
    1wxt: Solution structure of the SH3 domain of human hypothetical protein FLJ21522


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