EPB41L1

Protein-coding gene in the species Homo sapiens
EPB41L1
Identifiers
AliasesEPB41L1, 4.1N, MRD11, erythrocyte membrane protein band 4.1 like 1
External IDsOMIM: 602879; MGI: 103010; HomoloGene: 8126; GeneCards: EPB41L1; OMA:EPB41L1 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for EPB41L1
Genomic location for EPB41L1
Band20q11.23Start36,091,504 bp[1]
End36,232,799 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for EPB41L1
Genomic location for EPB41L1
Band2 H1|2 77.39 cMStart156,262,829 bp[2]
End156,385,134 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • superior vestibular nucleus

  • Pars compacta

  • pons

  • external globus pallidus

  • pars reticulata

  • parietal lobe

  • lateral nuclear group of thalamus

  • ventral tegmental area

  • postcentral gyrus

  • middle temporal gyrus
Top expressed in
  • visual cortex

  • primary visual cortex

  • superior frontal gyrus

  • cerebellar cortex

  • dentate gyrus of hippocampal formation granule cell

  • pontine nuclei

  • central gray substance of midbrain

  • olfactory tubercle

  • primary motor cortex

  • medial vestibular nucleus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • cytoskeletal protein binding
  • actin binding
  • protein binding
  • structural molecule activity
  • structural constituent of cytoskeleton
Cellular component
  • cytoplasm
  • cytosol
  • cytoskeleton
  • plasma membrane
Biological process
  • cortical actin cytoskeleton organization
  • actomyosin structure organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2036

13821

Ensembl

ENSG00000088367

ENSMUSG00000027624

UniProt

Q9H4G0
Q4VXN0

Q9Z2H5

RefSeq (mRNA)

NM_001258329
NM_001258330
NM_001258331
NM_012156
NM_177996

NM_001003815
NM_001006664
NM_001291120
NM_001291121
NM_001291122

NM_001291123
NM_013510
NM_001368800
NM_001368801
NM_001368802
NM_001368803
NM_001368804

RefSeq (protein)

NP_001245258
NP_001245259
NP_001245260
NP_036288
NP_818932

NP_001006665
NP_001278049
NP_001278050
NP_001278051
NP_001278052

NP_038538
NP_001355729
NP_001355730
NP_001355731
NP_001355732
NP_001355733

Location (UCSC)Chr 20: 36.09 – 36.23 MbChr 2: 156.26 – 156.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Band 4.1-like protein 1 is a protein that in humans is encoded by the EPB41L1 gene.[5][6][7]

Function

Erythrocyte membrane protein band 4.1 (EPB41) is a multifunctional protein that mediates interactions between the erythrocyte cytoskeleton and the overlying plasma membrane. The protein encoded by this gene is a neuronally-enriched protein that is structurally similar to EPB41. The encoded protein binds and stabilizes D2 and D3 dopamine receptors at the neuronal plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them has been determined.[7]

Interactions

EPB41L1 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000088367 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027624 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kim AC, Van Huffel C, Lutchman M, Chishti AH (June 1998). "Radiation hybrid mapping of EPB41L1, a novel protein 4.1 homologue, to human chromosome 20q11.2-q12". Genomics. 49 (1): 165–6. doi:10.1006/geno.1998.5212. PMID 9570967.
  6. ^ Peters LL, Weier HU, Walensky LD, Snyder SH, Parra M, Mohandas N, Conboy JG (January 1999). "Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human". Genomics. 54 (2): 348–50. doi:10.1006/geno.1998.5537. PMID 9828140.
  7. ^ a b "Entrez Gene: EPB41L1 erythrocyte membrane protein band 4.1-like 1".
  8. ^ Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH (December 2000). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N". Cell. 103 (6): 919–30. doi:10.1016/S0092-8674(00)00195-1. PMID 11136977.
  9. ^ a b Binda AV, Kabbani N, Lin R, Levenson R (September 2002). "D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N". Mol. Pharmacol. 62 (3): 507–13. doi:10.1124/mol.62.3.507. PMID 12181426. S2CID 19901660.
  10. ^ Maximov A, Tang TS, Bezprozvanny I (February 2003). "Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons". Mol. Cell. Neurosci. 22 (2): 271–83. doi:10.1016/s1044-7431(02)00027-1. PMID 12676536. S2CID 2317354.
  11. ^ Ye K, Compton DA, Lai MM, Walensky LD, Snyder SH (December 1999). "Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor". J. Neurosci. 19 (24): 10747–56. doi:10.1523/JNEUROSCI.19-24-10747.1999. PMC 6784956. PMID 10594058.

Further reading

  • Calinisan V, Gravem D, Chen RP, Brittin S, Mohandas N, Lecomte MC, Gascard P (2006). "New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium" (PDF). Front. Biosci. 11: 1646–66. doi:10.2741/1911. PMID 16368544. S2CID 26325962.
  • Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
  • Walensky LD, Blackshaw S, Liao D, Watkins CC, Weier HU, Parra M, Huganir RL, Conboy JG, Mohandas N, Snyder SH (1999). "A novel neuron-enriched homolog of the erythrocyte membrane cytoskeletal protein 4.1". J. Neurosci. 19 (15): 6457–67. doi:10.1523/JNEUROSCI.19-15-06457.1999. PMC 6782826. PMID 10414974.
  • Ye K, Compton DA, Lai MM, Walensky LD, Snyder SH (2000). "Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor". J. Neurosci. 19 (24): 10747–56. doi:10.1523/JNEUROSCI.19-24-10747.1999. PMC 6784956. PMID 10594058.
  • Shen L, Liang F, Walensky LD, Huganir RL (2001). "Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association". J. Neurosci. 20 (21): 7932–40. doi:10.1523/jneurosci.20-21-07932.2000. PMC 6772741. PMID 11050113.
  • Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH (2001). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N". Cell. 103 (6): 919–30. doi:10.1016/S0092-8674(00)00195-1. PMID 11136977.
  • Binda AV, Kabbani N, Lin R, Levenson R (2002). "D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N". Mol. Pharmacol. 62 (3): 507–13. doi:10.1124/mol.62.3.507. PMID 12181426. S2CID 19901660.
  • Zhang S, Mizutani A, Hisatsune C, Higo T, Bannai H, Nakayama T, Hattori M, Mikoshiba K (2003). "Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells". J. Biol. Chem. 278 (6): 4048–56. doi:10.1074/jbc.M209960200. PMC 2366074. PMID 12444087.
  • Coleman SK, Cai C, Mottershead DG, Haapalahti JP, Keinänen K (2003). "Surface expression of GluR-D AMPA receptor is dependent on an interaction between its C-terminal domain and a 4.1 protein". J. Neurosci. 23 (3): 798–806. doi:10.1523/JNEUROSCI.23-03-00798.2003. PMC 6741938. PMID 12574408.
  • Maximov A, Tang TS, Bezprozvanny I (2003). "Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons". Mol. Cell. Neurosci. 22 (2): 271–83. doi:10.1016/S1044-7431(02)00027-1. PMID 12676536. S2CID 2317354.
  • Nagaraja GM, Kandpal RP (2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins". Biochem. Biophys. Res. Commun. 313 (3): 654–65. doi:10.1016/j.bbrc.2003.12.001. PMID 14697242.
  • Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.


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