Diphepanol
Names | |
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IUPAC name 1,1-diphenyl-2-(piperidin-1-yl)propan-1-ol | |
Identifiers | |
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3D model (JSmol) |
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ChemSpider |
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ECHA InfoCard | 100.007.372 |
PubChem CID |
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UNII |
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CompTox Dashboard (EPA) |
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InChI
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Properties | |
Chemical formula | C20H25NO |
Molar mass | 295.42 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
Diphepanol is a cough suppressant (antitussive).
Synthesis
Ex 1: The α-keto bromination of propiophenone [93-55-0] (1) gives 2-bromopropiophenone [2114-00-3] (2). Displacement of the halogen and hence amination with piperidine [110-89-4] gave alpha-Piperidinopropiophenone, CID:458526 (3). and addition of phenyl Grignard reagent to give the benzhydrol product, and hence Dihepanol (4).
See also
- Diphenidol
- Clofedanol
References
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Cough and cold preparations (R05)
- Althea root
- Ammonium chloride
- Antimony pentasulfide
- Cineole
- Creosote
- Guaiacolsulfonate
- Guaifenesin (+codeine, +hydrocodone, +oxomemazine)
- Hederae helicis folium
- Ipecacuanha (Syrup of ipecac)
- Levoverbenone
- Potassium iodide
- Senega
- Tyloxapol
- Acetylcysteine#
- Ambroxol
- Bromhexine
- Carbocisteine
- Dembrexine hydrochloride
- Domiodol
- Dornase alfa
- Eprazinone
- Erdosteine
- Letosteine
- Mannitol
- Mesna
- Neltenexine
- Sobrerol
- Stepronin
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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