Derrubone
![]() | |
Names | |
---|---|
IUPAC name 5,7-Dihydroxy-6-(3-methylbut-2-en-1-yl)-3′,4′-[methylenebis(oxy)]isoflavone | |
Systematic IUPAC name 3-(2H-1,3-Benzodioxol-5-yl)-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-1-benzopyran-4-one | |
Other names 5,7-Dihydroxy-3',4'-methylenedioxy-6-prenylisoflavone | |
Identifiers | |
CAS Number |
|
3D model (JSmol) |
|
ChEMBL |
|
ChemSpider |
|
PubChem CID |
|
UNII |
|
CompTox Dashboard (EPA) |
|
InChI
| |
| |
Properties | |
Chemical formula | C21H18O6 |
Molar mass | 366.369 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ![]() ![]() ![]() Infobox references |
Chemical compound
Derrubone is a prenylated isoflavone, a type of flavonoid. It was originally isolated from the Indian tree Derris robusta.[1] Recent research indicates that it acts as an inhibitor of Hsp90 to its function as a chaperone protein.[2]
References
- ^ East AJ, Ollis WD, Wheeler RE (1969). "Natural occurrence of 3-aryl-4-hydroxycoumarins. Part I. Phytochemical examination of Derris robusta(roxb.) benth". J. Chem. Soc. C. 3 (3): 365–74. doi:10.1039/J39690000365.
- ^ Hadden MK, Galam L, Gestwicki JE, Matts RL, Blagg BS (December 2007). "Derrubone, an inhibitor of the Hsp90 protein folding machinery". J. Nat. Prod. 70 (12): 2014–8. doi:10.1021/np070190s. PMID 18020309.
- v
- t
- e
Isoflavones and their glycosides
- Bidwillol A
- Derrubone
- Luteone
- 7-O-Methylluteone
- Wighteone
- Alpinumisoflavone
- Barbigerone
- Di-O-methylalpinumisoflavone
- 4'-methyl-alpinumisoflavone
- Anagyroidisoflavone A and B
- Irilone
- Pseudobaptigenin
- Rotenoids
![]() | This article about an aromatic compound is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e