DEFB119

Protein-coding gene in humans
DEFB119
Identifiers
AliasesDEFB119, DEFB-19, DEFB-20, DEFB120, ESC42-RELA, ESC42-RELB, DEFB20, defensin beta 119
External IDsOMIM: 615997; MGI: 2385955; HomoloGene: 17045; GeneCards: DEFB119; OMA:DEFB119 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for DEFB119
Genomic location for DEFB119
Band20q11.21Start31,377,164 bp[1]
End31,390,590 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for DEFB119
Genomic location for DEFB119
Band2|2 H1Start152,418,006 bp[2]
End152,422,232 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus epididymis

  • right testis

  • left testis

  • testicle

  • tail of epididymis

  • buccal mucosa cell

  • caput epididymis

  • sperm

  • right coronary artery

  • retinal pigment epithelium
Top expressed in
  • Gonadal ridge

  • seminiferous tubule

  • spermatocyte

  • embryo

  • spermatid

  • cumulus cell

  • efferent ductule

  • epithelium of seminiferous tubule of testis

  • Sertoli cell

  • morula
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • lipopolysaccharide binding
Cellular component
  • extracellular region
  • cell surface
Biological process
  • defense response to bacterium
  • defense response
  • innate immune response
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

245932

246700

Ensembl

ENSG00000180483

ENSMUSG00000050645

UniProt

Q8N690

Q8K3I8

RefSeq (mRNA)

NM_001271209
NM_153289
NM_153323

NM_145157

RefSeq (protein)

NP_001258138
NP_695021
NP_697018

NP_660139

Location (UCSC)Chr 20: 31.38 – 31.39 MbChr 2: 152.42 – 152.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Beta-defensin 119 is a protein that in humans is encoded by the DEFB119 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000180483 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050645 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. Bibcode:2002PNAS...99.2129S. doi:10.1073/pnas.042692699. PMC 122330. PMID 11854508.
  6. ^ "Entrez Gene: DEFB119 defensin, beta 119".

Further reading

  • Lehrer RI, Ganz T (2002). "Defensins of vertebrate animals". Curr. Opin. Immunol. 14 (1): 96–102. doi:10.1016/S0952-7915(01)00303-X. PMID 11790538.
  • Raj PA, Dentino AR (2002). "Current status of defensins and their role in innate and adaptive immunity". FEMS Microbiol. Lett. 206 (1): 9–18. doi:10.1111/j.1574-6968.2002.tb10979.x. PMID 11786250.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Yamamoto M, Matsui Y (2003). "Testis-specific expression of a novel mouse defensin-like gene, Tdl". Mech. Dev. 116 (1–2): 217–21. doi:10.1016/S0925-4773(02)00144-2. PMID 12128228. S2CID 15160486.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.


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