Protein-coding gene in the species Homo sapiens
DCTN5 |
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Identifiers |
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Aliases | DCTN5, dynactin subunit 5 |
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External IDs | OMIM: 612962; MGI: 1891689; HomoloGene: 10998; GeneCards: DCTN5; OMA:DCTN5 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 16 (human)[1] |
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| Band | 16p12.2 | Start | 23,641,466 bp[1] |
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End | 23,677,472 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 7 (mouse)[2] |
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| Band | 7|7 F2 | Start | 121,732,264 bp[2] |
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End | 121,748,267 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - islet of Langerhans
- rectum
- stromal cell of endometrium
- smooth muscle tissue
- monocyte
- mucosa of esophagus
- ganglionic eminence
- lymph node
- epithelium of colon
- mucosa of transverse colon
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| Top expressed in | - dentate gyrus of hippocampal formation granule cell
- right kidney
- granulocyte
- superior frontal gyrus
- medial ganglionic eminence
- yolk sac
- pituitary gland
- tail of embryo
- cumulus cell
- blood
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | | Cellular component | - cytoplasm
- cytosol
- centrosome
- nuclear membrane
- chromosome, centromeric region
- cytoskeleton
- kinetochore
- nucleoplasm
- chromosome
| Biological process | - endoplasmic reticulum to Golgi vesicle-mediated transport
- aorta development
- ventricular septum development
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- coronary vasculature development
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001199011 NM_001199743 NM_032486 |
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RefSeq (protein) | |
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NP_001185940 NP_001186672 NP_115875 |
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Location (UCSC) | Chr 16: 23.64 – 23.68 Mb | Chr 7: 121.73 – 121.75 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Dynactin 5 (p25) is a protein that in humans is encoded by the DCTN5 gene.[5]
This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000166847 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030868 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: Dynactin 5 (p25)". Retrieved 2011-09-20.
Further reading
Eckley DM, Gill SR, Melkonian KA, Bingham JB, Goodson HV, Heuser JE, et al. (October 1999). "Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end". The Journal of Cell Biology. 147 (2): 307–320. doi:10.1083/jcb.147.2.307. PMC 2174220. PMID 10525537. Parisi G, Fornasari MS, Echave J (March 2004). "Dynactins p25 and p27 are predicted to adopt the LbetaH fold". FEBS Letters. 562 (1–3): 1–4. doi:10.1016/S0014-5793(04)00165-6. PMID 15043994. S2CID 84381211. Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, et al. (June 2007). "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls". Nature. 447 (7145): 661–678. Bibcode:2007Natur.447..661B. doi:10.1038/nature05911. PMC 2719288. PMID 17554300.