Collagen, type XXVIII, alpha 1

Protein found in humans
COL28A1
Identifiers
AliasesCOL28A1, COL28, collagen type XXVIII alpha 1, collagen type XXVIII alpha 1 chain
External IDsOMIM: 609996; MGI: 2685312; HomoloGene: 66345; GeneCards: COL28A1; OMA:COL28A1 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for COL28A1
Genomic location for COL28A1
Band7p21.3Start7,356,203 bp[1]
End7,535,873 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for COL28A1
Genomic location for COL28A1
Band6|6 A1Start7,997,808 bp[2]
End8,192,617 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • trigeminal ganglion

  • spinal ganglia

  • right uterine tube

  • bronchial epithelial cell

  • olfactory zone of nasal mucosa

  • epithelium of colon

  • parotid gland

  • muscle layer of sigmoid colon

  • anterior pituitary
Top expressed in
  • spermatocyte

  • spermatid

  • morula

  • zygote

  • esophagus

  • primary oocyte

  • quadriceps femoris muscle

  • lip

  • secondary oocyte

  • urinary bladder
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • peptidase inhibitor activity
  • serine-type endopeptidase inhibitor activity
  • extracellular matrix structural constituent
  • extracellular matrix structural constituent conferring tensile strength
Cellular component
  • extracellular region
  • basement membrane
  • collagen
  • endoplasmic reticulum lumen
  • extracellular matrix
  • extracellular space
  • collagen-containing extracellular matrix
Biological process
  • negative regulation of peptidase activity
  • cell adhesion
  • negative regulation of endopeptidase activity
  • extracellular matrix organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

340267

213945

Ensembl

ENSG00000215018

ENSMUSG00000068794

UniProt

Q2UY09

Q2UY11

RefSeq (mRNA)

NM_001037763

NM_001037865

RefSeq (protein)

NP_001032852

NP_001032954

Location (UCSC)Chr 7: 7.36 – 7.54 MbChr 6: 8 – 8.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Collagen, type XXVIII, alpha 1 also known as COL28A1 is a protein that in humans is encoded by the COL28A1 gene.[5] This protein belongs to a class of collagens that contain von Willebrand factor type A domains.[6] The protein is encoded by the COL28A1 gene which contains 45 exons and is found of the p arm of chromosome 7.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000215018 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068794 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Veit G, Kobbe B, Keene DR, Paulsson M, Koch M, Wagener R (Feb 2006). "Collagen XXVIII, a novel von Willebrand factor A domain-containing protein with many imperfections in the collagenous domain". The Journal of Biological Chemistry. 281 (6): 3494–504. doi:10.1074/jbc.M509333200. PMID 16330543.
  6. ^ a b "COL28A1 collagen, type XXVIII, alpha 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2015-09-25.
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Extracellular
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Collagen
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