CNOT1 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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4C0D, 4CQO, 4CRV, 4CRW, 4CT4, 4CT6, 4CT7, 4GMJ, 4GML, 4J8S, 5ANR, 5FU6, 5FU7 |
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Identifiers |
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Aliases | CNOT1, CDC39, NOT1, NOT1H, AD-005, CCR4-NOT transcription complex subunit 1, HPE12, VIBOS |
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External IDs | OMIM: 604917; MGI: 2442402; HomoloGene: 9453; GeneCards: CNOT1; OMA:CNOT1 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 16 (human)[1] |
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| Band | 16q21 | Start | 58,519,951 bp[1] |
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End | 58,629,885 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 8 (mouse)[2] |
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| Band | 8|8 D1 | Start | 96,446,079 bp[2] |
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End | 96,534,092 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - gonad
- left testis
- right testis
- ventricular zone
- ganglionic eminence
- mucosa of transverse colon
- skin of abdomen
- skin of leg
- granulocyte
- epithelium of colon
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| Top expressed in | - tail of embryo
- genital tubercle
- spermatocyte
- ventricular zone
- spermatid
- yolk sac
- neural layer of retina
- zygote
- granulocyte
- morula
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| More reference expression data |
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BioGPS |
| More reference expression data |
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Gene ontology |
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Molecular function | - poly(A)-specific ribonuclease activity
- protein domain specific binding
- protein binding
- retinoic acid receptor binding
- armadillo repeat domain binding
- molecular adaptor activity
- estrogen receptor binding
- RNA binding
| Cellular component | - membrane
- CCR4-NOT complex
- peroxisomal membrane
- P-body
- CCR4-NOT core complex
- nucleus
- extracellular space
- cytoplasm
- cytosol
| Biological process | - nuclear-transcribed mRNA poly(A) tail shortening
- negative regulation of translation
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
- regulation of transcription, DNA-templated
- negative regulation of retinoic acid receptor signaling pathway
- regulation of stem cell population maintenance
- negative regulation of transcription by RNA polymerase II
- positive regulation of mRNA catabolic process
- transcription, DNA-templated
- multicellular organism development
- positive regulation of cytoplasmic mRNA processing body assembly
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- gene silencing by miRNA
- gene silencing
- negative regulation of intracellular estrogen receptor signaling pathway
- regulation of translation
- RNA phosphodiester bond hydrolysis, exonucleolytic
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001265612 NM_016284 NM_206999 |
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NM_001205226 NM_153164 NM_178078 NM_001372351 NM_001372353 |
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RefSeq (protein) | |
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NP_001252541 NP_057368 NP_996882 |
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NP_001192155 NP_694804 NP_835179 NP_001359280 NP_001359282 |
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Location (UCSC) | Chr 16: 58.52 – 58.63 Mb | Chr 8: 96.45 – 96.53 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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