CLDN7

Protein-coding gene in humans

CLDN7
Identifiers
AliasesCLDN7, CEPTRL2, CLDN-7, CPETRL2, Hs.84359, claudin-1, claudin 7
External IDsOMIM: 609131; MGI: 1859285; HomoloGene: 9649; GeneCards: CLDN7; OMA:CLDN7 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for CLDN7
Genomic location for CLDN7
Band17p13.1Start7,259,903 bp[1]
End7,263,983 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for CLDN7
Genomic location for CLDN7
Band11|11 B3Start69,855,605 bp[2]
End69,858,711 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • duodenum

  • rectum

  • right uterine tube

  • olfactory zone of nasal mucosa

  • minor salivary glands

  • body of pancreas

  • left lobe of thyroid gland

  • islet of Langerhans

  • right lobe of thyroid gland
Top expressed in
  • crypt of lieberkuhn of small intestine

  • left colon

  • migratory enteric neural crest cell

  • ileum

  • duodenum

  • yolk sac

  • medullary collecting duct

  • jejunum

  • mucosa of urinary bladder

  • transitional epithelium of urinary bladder
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • structural molecule activity
  • identical protein binding
  • protein binding
  • cell adhesion molecule binding
Cellular component
  • bicellular tight junction
  • cell junction
  • basolateral plasma membrane
  • membrane
  • lateral plasma membrane
  • integral component of membrane
  • apicolateral plasma membrane
  • plasma membrane
Biological process
  • negative regulation of protein homooligomerization
  • negative regulation of cell adhesion
  • positive regulation of cell motility
  • negative regulation of apoptotic process
  • positive regulation of cell population proliferation
  • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
  • response to ethanol
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1366

53624

Ensembl

ENSG00000181885
ENSG00000288292

ENSMUSG00000018569

UniProt

O95471

Q9Z261

RefSeq (mRNA)

NM_001307
NM_001185022
NM_001185023

NM_001193619
NM_016887

RefSeq (protein)

NP_001171951
NP_001171952
NP_001298

NP_001180548
NP_058583

Location (UCSC)Chr 17: 7.26 – 7.26 MbChr 11: 69.86 – 69.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Claudin-7 is a protein that in humans is encoded by the CLDN7 gene.[5][6] It belongs to the group of claudins.

Claudins, such as CLDN7, are involved in the formation of tight junctions between epithelial cells. Tight junctions restrict lateral diffusion of lipids and membrane proteins, and thereby physically define the border between the apical and basolateral compartments of epithelial cells (Zheng et al., 2003).[supplied by OMIM][6]

References

  1. ^ a b c ENSG00000288292 GRCh38: Ensembl release 89: ENSG00000181885, ENSG00000288292 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018569 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Morita K, Furuse M, Fujimoto K, Tsukita S (Mar 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc Natl Acad Sci U S A. 96 (2): 511–6. Bibcode:1999PNAS...96..511M. doi:10.1073/pnas.96.2.511. PMC 15167. PMID 9892664.
  6. ^ a b "Entrez Gene: CLDN7 claudin 7".

Further reading

  • Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502. S2CID 26473781.
  • Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159.
  • Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
  • Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
  • González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Peacock RE, Keen TJ, Inglehearn CF (1998). "Analysis of a human gene homologous to rat ventral prostate.1 protein". Genomics. 46 (3): 443–9. doi:10.1006/geno.1997.5033. PMID 9441748.
  • Itoh M, Furuse M, Morita K, et al. (2000). "Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins". J. Cell Biol. 147 (6): 1351–63. doi:10.1083/jcb.147.6.1351. PMC 2168087. PMID 10601346.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kominsky SL, Argani P, Korz D, et al. (2003). "Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast". Oncogene. 22 (13): 2021–33. doi:10.1038/sj.onc.1206199. PMID 12673207. S2CID 20318884.
  • Ban Y, Dota A, Cooper LJ, et al. (2003). "Tight junction-related protein expression and distribution in human corneal epithelium". Exp. Eye Res. 76 (6): 663–9. doi:10.1016/S0014-4835(03)00054-X. PMID 12742348.
  • Zheng JY, Yu D, Foroohar M, et al. (2004). "Regulation of the expression of the prostate-specific antigen by claudin-7". J. Membr. Biol. 194 (3): 187–97. doi:10.1007/s00232-003-2038-4. PMID 14502431. S2CID 8482475.
  • Resnick MB, Konkin T, Routhier J, et al. (2005). "Claudin-1 is a strong prognostic indicator in stage II colonic cancer: a tissue microarray study". Mod. Pathol. 18 (4): 511–8. doi:10.1038/modpathol.3800301. PMID 15475928. S2CID 28512983.
  • Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.


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