CD5L

Protein-coding gene in the species Homo sapiens
CD5L
Identifiers
AliasesCD5L, AIM, API6, PRO229, SP-ALPHA, Spalpha, CT-2, hAIM, CD5 molecule like
External IDsOMIM: 602592; MGI: 1334419; HomoloGene: 55936; GeneCards: CD5L; OMA:CD5L - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CD5L
Genomic location for CD5L
Band1q23.1Start157,830,911 bp[1]
End157,898,256 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for CD5L
Genomic location for CD5L
Band3|3 F1Start87,265,188 bp[2]
End87,278,380 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • spleen

  • trabecular bone

  • liver

  • testicle

  • right lobe of liver

  • buccal mucosa cell

  • lymph node

  • bone marrow

  • bone marrow cells

  • placenta
Top expressed in
  • stroma of bone marrow

  • fetal liver hematopoietic progenitor cell

  • mesenteric lymph nodes

  • left lobe of liver

  • spleen

  • calvaria

  • tibiofemoral joint

  • granulocyte

  • human fetus

  • subcutaneous adipose tissue
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • scavenger receptor activity
Cellular component
  • cytoplasm
  • extracellular region
  • extracellular exosome
  • blood microparticle
  • membrane
  • extracellular space
  • plasma membrane
  • cell surface
Biological process
  • cellular defense response
  • inflammatory response
  • receptor-mediated endocytosis
  • immune system process
  • apoptotic process
  • vesicle-mediated transport
  • regulation of complement activation
  • positive regulation of complement-dependent cytotoxicity
  • endocytosis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

922

11801

Ensembl

ENSG00000073754

ENSMUSG00000015854

UniProt

O43866

Q9QWK4

RefSeq (mRNA)

NM_005894
NM_001347698

NM_009690

RefSeq (protein)

NP_001334627
NP_005885

NP_033820

Location (UCSC)Chr 1: 157.83 – 157.9 MbChr 3: 87.27 – 87.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD5 antigen-like is a protein (also known as AIM Apoptosis Inhibitor of Macrophages) that in humans is encoded by the CD5L gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000073754 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015854 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gebe JA, Kiener PA, Ring HZ, Li X, Francke U, Aruffo A (Apr 1997). "Molecular cloning, mapping to human chromosome 1 q21-q23, and cell binding characteristics of Spalpha, a new member of the scavenger receptor cysteine-rich (SRCR) family of proteins". J Biol Chem. 272 (10): 6151–8. doi:10.1074/jbc.272.10.6151. PMID 9045627.
  6. ^ "Entrez Gene: CD5L CD5 molecule-like".

Further reading

  • Tissot JD, Schifferli JA, Hochstrasser DF, et al. (1994). "Two-dimensional polyacrylamide gel electrophoresis analysis of cryoglobulins and identification of an IgM-associated peptide". J. Immunol. Methods. 173 (1): 63–75. doi:10.1016/0022-1759(94)90284-4. PMID 8034987.
  • Tissot JD, Sanchez JC, Vuadens F, et al. (2002). "IgM are associated to Sp alpha (CD5 antigen-like)". Electrophoresis. 23 (7–8): 1203–6. doi:10.1002/1522-2683(200204)23:7/8<1203::AID-ELPS1203>3.0.CO;2-1. PMID 11981870. S2CID 94662015.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Sarrias MR, Roselló S, Sánchez-Barbero F, et al. (2005). "A role for human Sp alpha as a pattern recognition receptor". J. Biol. Chem. 280 (42): 35391–8. doi:10.1074/jbc.M505042200. hdl:2445/176948. PMID 16030018.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.


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