CALML3

Protein-coding gene in the species Homo sapiens
CALML3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1GGZ

Identifiers
AliasesCALML3, CLP, calmodulin like 3
External IDsOMIM: 114184; MGI: 1917655; HomoloGene: 133078; GeneCards: CALML3; OMA:CALML3 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for CALML3
Genomic location for CALML3
Band10p15.1Start5,524,961 bp[1]
End5,526,771 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for CALML3
Genomic location for CALML3
Band13|13 A1Start3,852,896 bp[2]
End3,854,316 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gums

  • gingival epithelium

  • vulva

  • skin of arm

  • mucosa of pharynx

  • oral cavity

  • skin of leg

  • skin of abdomen

  • cervix epithelium

  • hair follicle
Top expressed in
  • conjunctival fornix

  • lip

  • esophagus

  • cornea

  • skin of external ear

  • ciliary body

  • skin of back

  • belly cord

  • parotid gland

  • skin of abdomen
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • metal ion binding
  • protein binding
  • calcium ion binding
Cellular component
  • extracellular exosome
  • nucleus
Biological process
  • calcium-mediated signaling
  • spindle pole body organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

810

70405

Ensembl

ENSG00000178363

ENSMUSG00000063130

UniProt

P27482

Q9D6P8

RefSeq (mRNA)

NM_005185

NM_027416

RefSeq (protein)

NP_005176

NP_081692

Location (UCSC)Chr 10: 5.52 – 5.53 MbChr 13: 3.85 – 3.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calmodulin-like protein 3 is a protein that in humans is encoded by the CALML3 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178363 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063130 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Koller M, Strehler EE (May 1993). "Functional analysis of the promoters of the human CaMIII calmodulin gene and of the intronless gene coding for a calmodulin-like protein". Biochim Biophys Acta. 1163 (1): 1–9. doi:10.1016/0167-4838(93)90271-R. PMID 8476923.
  6. ^ "Entrez Gene: CALML3 calmodulin-like 3".

External links

Further reading

  • Rhyner JA, Koller M, Durussel-Gerber I, et al. (1993). "Characterization of the human calmodulin-like protein expressed in Escherichia coli". Biochemistry. 31 (51): 12826–32. doi:10.1021/bi00166a017. PMID 1334432.
  • Yaswen P, Smoll A, Peehl DM, et al. (1990). "Down-regulation of a calmodulin-related gene during transformation of human mammary epithelial cells". Proc. Natl. Acad. Sci. U.S.A. 87 (19): 7360–4. Bibcode:1990PNAS...87.7360Y. doi:10.1073/pnas.87.19.7360. PMC 54746. PMID 2217169.
  • Koller M, Strehler EE (1988). "Characterization of an intronless human calmodulin-like pseudogene". FEBS Lett. 239 (1): 121–8. doi:10.1016/0014-5793(88)80558-1. PMID 3181418. S2CID 29139707.
  • Berchtold MW, Koller M, Egli R, et al. (1993). "Localization of the intronless gene coding for calmodulin-like protein CLP to human chromosome 10p13-ter". Hum. Genet. 90 (5): 496–500. doi:10.1007/BF00217447. PMID 8428750. S2CID 41567243.
  • Durussel I, Rhyner JA, Strehler EE, Cox JA (1993). "Cation binding and conformation of human calmodulin-like protein". Biochemistry. 32 (23): 6089–94. doi:10.1021/bi00074a021. PMID 8507643.
  • Rogers MS, Strehler EE (2001). "The tumor-sensitive calmodulin-like protein is a specific light chain of human unconventional myosin X." J. Biol. Chem. 276 (15): 12182–9. doi:10.1074/jbc.M010056200. PMID 11278607.
  • Rogers MS, Kobayashi T, Pittelkow MR, Strehler EE (2001). "Human calmodulin-like protein is an epithelial-specific protein regulated during keratinocyte differentiation". Exp. Cell Res. 267 (2): 216–24. doi:10.1006/excr.2001.5254. PMID 11426940.
  • Han BG, Han M, Sui H, et al. (2002). "Crystal structure of human calmodulin-like protein: insights into its functional role". FEBS Lett. 521 (1–3): 24–30. doi:10.1016/S0014-5793(02)02780-1. PMID 12067719. S2CID 20087760.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Bennett RD, Mauer AS, Strehler EE (2007). "Calmodulin-like protein increases filopodia-dependent cell motility via up-regulation of myosin-10". J. Biol. Chem. 282 (5): 3205–12. doi:10.1074/jbc.M607174200. PMID 17130134.
  • v
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  • 1ggz: CRYSTAL STRUCTURE OF THE CALMODULIN-LIKE PROTEIN (HCLP) FROM HUMAN EPITHELIAL CELLS
    1ggz: CRYSTAL STRUCTURE OF THE CALMODULIN-LIKE PROTEIN (HCLP) FROM HUMAN EPITHELIAL CELLS


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