B4GALNT2

Protein-coding gene in the species Homo sapiens
B4GALNT2
Identifiers
AliasesB4GALNT2, B4GALT, GALGT2, beta-1,4-N-acetyl-galactosaminyltransferase 2
External IDsOMIM: 111730; MGI: 1342058; HomoloGene: 7329; GeneCards: B4GALNT2; OMA:B4GALNT2 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for B4GALNT2
Genomic location for B4GALNT2
Band17q21.32Start49,132,460 bp[1]
End49,176,840 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for B4GALNT2
Genomic location for B4GALNT2
Band11 D|11 59.02 cMStart95,756,769 bp[2]
End95,805,717 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • rectum

  • appendix

  • body of stomach

  • gonad

  • epithelium of colon

  • human kidney

  • left lobe of thyroid gland

  • right lobe of thyroid gland

  • gallbladder
Top expressed in
  • duodenum

  • crypt of lieberkuhn of small intestine

  • yolk sac

  • parotid gland

  • jejunum

  • intestinal villus

  • ileum

  • Paneth cell

  • muscle of thigh

  • left colon
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • hexosyltransferase activity
  • glycosyltransferase activity
  • acetylgalactosaminyltransferase activity
Cellular component
  • integral component of membrane
  • integral component of Golgi membrane
  • Golgi apparatus
  • membrane
  • Golgi membrane
Biological process
  • UDP-N-acetylglucosamine metabolic process
  • protein glycosylation
  • UDP-N-acetylgalactosamine metabolic process
  • lipid glycosylation
  • negative regulation of cell-cell adhesion
  • protein N-linked glycosylation via asparagine
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

124872

14422

Ensembl

ENSG00000167080

ENSMUSG00000013418

UniProt

Q8NHY0

Q09199

RefSeq (mRNA)

NM_001159387
NM_001159388
NM_153446

NM_008081

RefSeq (protein)

NP_001152859
NP_001152860
NP_703147

NP_032107

Location (UCSC)Chr 17: 49.13 – 49.18 MbChr 11: 95.76 – 95.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Beta-1,4 N-acetylgalactosaminyltransferase 2 is an enzyme that in humans is encoded by the B4GALNT2 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167080 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000013418 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dohi T, Yuyama Y, Natori Y, Smith PL, Lowe JB, Oshima M (Sep 1996). "Detection of N-acetylgalactosaminyltransferase mRNA which determines expression of Sda blood group carbohydrate structure in human gastrointestinal mucosa and cancer". International Journal of Cancer. 67 (5): 626–31. doi:10.1002/(SICI)1097-0215(19960904)67:5<626::AID-IJC6>3.0.CO;2-W. PMID 8782649.
  6. ^ Montiel MD, Krzewinski-Recchi MA, Delannoy P, Harduin-Lepers A (Jul 2003). "Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain". The Biochemical Journal. 373 (Pt 2): 369–79. doi:10.1042/BJ20021892. PMC 1223490. PMID 12678917.
  7. ^ "Entrez Gene: B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2".

Further reading

  • Berger EG (Feb 2002). "Ectopic localizations of Golgi glycosyltransferases". Glycobiology. 12 (2): 29R–36R. doi:10.1093/glycob/12.2.29R. PMID 11886838.
  • Wang HR, Hsieh CY, Twu YC, Yu LC (Jan 2008). "Expression of the human Sd(a) beta-1,4-N-acetylgalactosaminyltransferase II gene is dependent on the promoter methylation status". Glycobiology. 18 (1): 104–13. doi:10.1093/glycob/cwm120. PMID 17965433.
  • Kawamura YI, Kawashima R, Fukunaga R, Hirai K, Toyama-Sorimachi N, Tokuhara M, Shimizu T, Dohi T (Jul 2005). "Introduction of Sd(a) carbohydrate antigen in gastrointestinal cancer cells eliminates selectin ligands and inhibits metastasis". Cancer Research. 65 (14): 6220–7. doi:10.1158/0008-5472.CAN-05-0639. PMID 16024623.
  • Lo Presti L, Cabuy E, Chiricolo M, Dall'Olio F (Nov 2003). "Molecular cloning of the human beta1,4 N-acetylgalactosaminyltransferase responsible for the biosynthesis of the Sd(a) histo-blood group antigen: the sequence predicts a very long cytoplasmic domain". Journal of Biochemistry. 134 (5): 675–82. doi:10.1093/jb/mvg192. PMID 14688233.
  • Piller F, Blanchard D, Huet M, Cartron JP (Jun 1986). "Identification of a alpha-NeuAc-(2----3)-beta-D-galactopyranosyl N-acetyl-beta-D-galactosaminyltransferase in human kidney". Carbohydrate Research. 149 (1): 171–84. doi:10.1016/S0008-6215(00)90376-8. PMID 2425965.
  • Li PT, Liao CJ, Wu WG, Yu LC, Chu ST (Jun 2011). "Progesterone-regulated B4galnt2 expression is a requirement for embryo implantation in mice" (PDF). Fertility and Sterility. 95 (7): 2404–9, 2409.e1–3. doi:10.1016/j.fertnstert.2011.03.043. PMID 21481371.


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