ARL8B

Protein-coding gene in the species Homo sapiens

ARL8B

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2AL7

Identifiers

Aliases

ARL8B, ARL10C, Gie1, ADP ribosylation factor like GTPase 8B

External IDs

OMIM: 616596; MGI: 1914416; HomoloGene: 10056; GeneCards: ARL8B; OMA:ARL8B - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3p26.1	Start	5,122,249 bp^[1]
Band	3p26.1	End	5,180,911 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6\|6 E2	Start	108,760,060 bp^[2]
Band	6\|6 E2	End	108,802,239 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

middle temporal gyrus

Brodmann area 23

lateral nuclear group of thalamus

postcentral gyrus

amniotic fluid

Brodmann area 46

pons

orbitofrontal cortex

gingival epithelium

entorhinal cortex

Top expressed in

dentate gyrus of hippocampal formation granule cell

superior frontal gyrus

muscle of thigh

subiculum

tail of embryo

anterior amygdaloid area

olfactory tubercle

ventral tegmental area

dorsomedial hypothalamic nucleus

prefrontal cortex

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding GDP binding alpha-tubulin binding GTP binding GTPase activity beta-tubulin binding protein binding
Cellular component	cytoplasm endosome membrane late endosome membrane spindle intracellular anatomical structure midbody spindle midzone lysosome extracellular exosome cytoskeleton lysosomal membrane vacuolar membrane axon synapse axon cytoplasm cell junction cell projection
Biological process	chromosome segregation small GTPase mediated signal transduction cell division cell cycle lysosome localization anterograde axonal transport protein transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


55207


67166

Ensembl


ENSG00000134108


ENSMUSG00000030105

UniProt


Q9NVJ2


Q9CQW2

RefSeq (mRNA)


NM_018184


NM_026011

RefSeq (protein)


NP_060654


NP_080287

Location (UCSC)

Chr 3: 5.12 – 5.18 Mb

Chr 6: 108.76 – 108.8 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

ADP-ribosylation factor-like protein 8B is a protein that in humans is encoded by the ARL8B gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134108 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030105 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
^ "Entrez Gene: ARL8B ADP-ribosylation factor-like 8B".

External links

Human ARL8B genome location and ARL8B gene details page in the UCSC Genome Browser.

Bagshaw RD, Callahan JW, Mahuran DJ (2006). "The Arf-family protein, Arl8b, is involved in the spatial distribution of lysosomes". Biochem. Biophys. Res. Commun. 344 (4): 1186–91. doi:10.1016/j.bbrc.2006.03.221. PMID 16650381.
Hofmann I, Munro S (2006). "An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility". J. Cell Sci. 119 (Pt 8): 1494–503. doi:10.1242/jcs.02958. PMID 16537643.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells" (PDF). Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788. Archived from the original (PDF) on 2019-02-24.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Okai T, Araki Y, Tada M, et al. (2005). "Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation". J. Cell Sci. 117 (Pt 20): 4705–15. doi:10.1242/jcs.01347. PMID 15331635.
Secombe J, Parkhurst SM (2004). "Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein". J. Biol. Chem. 279 (17): 17126–33. doi:10.1074/jbc.M310097200. PMID 14871887.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.