ARIH2

Protein-coding gene in humans

ARIH2
Identifiers
AliasesARIH2, ARI2, TRIAD1, ariadne RBR E3 ubiquitin protein ligase 2
External IDsOMIM: 605615; MGI: 1344361; HomoloGene: 48424; GeneCards: ARIH2; OMA:ARIH2 - orthologs
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[1]
Chromosome 9 (mouse)
Genomic location for ARIH2
Genomic location for ARIH2
Band9|9 F2Start108,480,141 bp[1]
End108,526,585 bp[1]
Gene ontology
Molecular function
  • ubiquitin protein ligase activity
  • metal ion binding
  • ubiquitin-protein transferase activity
  • protein binding
  • transferase activity
  • ubiquitin conjugating enzyme binding
  • zinc ion binding
Cellular component
  • cytoplasm
  • nucleus
  • nucleoplasm
  • Cul5-RING ubiquitin ligase complex
Biological process
  • developmental cell growth
  • positive regulation of protein targeting to mitochondrion
  • protein K63-linked ubiquitination
  • hematopoietic stem cell proliferation
  • protein polyubiquitination
  • multicellular organism development
  • protein K48-linked ubiquitination
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process
  • protein ubiquitination
  • ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10425

23807

Ensembl

ENSG00000177479

ENSMUSG00000064145

UniProt

O95376

Q9Z1K6

RefSeq (mRNA)

NM_006321
NM_001317333
NM_001317334

NM_011790
NM_001357283
NM_001357285
NM_001357286

RefSeq (protein)
NP_001304262
NP_001304263
NP_006312
NP_001336138
NP_001336139

NP_001336140
NP_001336141
NP_001336142
NP_001336143
NP_001336144
NP_001336145
NP_001336146
NP_001336147
NP_001336148
NP_001336149
NP_001336150
NP_001336151
NP_001336152
NP_001336153
NP_001336154
NP_001336155
NP_001336156
NP_001336157
NP_001336158
NP_001336159

NP_035920
NP_001344212
NP_001344214
NP_001344215

Location (UCSC)n/aChr 9: 108.48 – 108.53 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Protein ariadne-2 homolog is a protein that in humans is encoded by the ARIH2 gene.[4][5]

Function

ARIH2 influences development of Mll-Ell-induced acute myeloid leukemia and regulate the proliferation,[6] DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination,[7] ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.[8]

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064145 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ van der Reijden BA, Erpelinck-Verschueren CA, Löwenberg B, Jansen JH (July 1999). "TRIADs: a new class of proteins with a novel cysteine-rich signature". Protein Science. 8 (7): 1557–1561. doi:10.1110/ps.8.7.1557. PMC 2144383. PMID 10422847.
  5. ^ "Entrez Gene: ARIH2 ariadne homolog 2 (Drosophila)".
  6. ^ Wang H, Bei L, Shah CA, Huang W, Platanias LC, Eklund EA (May 2018). "The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia". Oncogene. 37 (19): 2532–2544. doi:10.1038/s41388-018-0131-5. PMC 5945580. PMID 29459712.
  7. ^ Geng S, Peng W, Wang X, Hu X, Liang H, Hou J, et al. (June 2022). "ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination". Cell Death & Disease. 13 (6): 564. doi:10.1038/s41419-022-04965-9. PMC 9218151. PMID 35732617.
  8. ^ Kawashima A, Karasawa T, Tago K, Kimura H, Kamata R, Usui-Kawanishi F, et al. (November 2017). "ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages". Journal of Immunology. 199 (10): 3614–3622. doi:10.4049/jimmunol.1700184. PMID 29021376.

Further reading

  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Aguilera M, Oliveros M, Martínez-Padrón M, Barbas JA, Ferrús A (July 2000). "Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins". Genetics. 155 (3): 1231–1244. doi:10.1093/genetics/155.3.1231. PMC 1461160. PMID 10880484.
  • Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, et al. (August 2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 97 (17): 9543–9548. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
  • Wong ES, Fong CW, Lim J, Yusoff P, Low BC, Langdon WY, Guy GR (September 2002). "Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling". The EMBO Journal. 21 (18): 4796–4808. doi:10.1093/emboj/cdf493. PMC 126289. PMID 12234920.
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–716. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Marteijn JA, van Emst L, Erpelinck-Verschueren CA, Nikoloski G, Menke A, de Witte T, et al. (December 2005). "The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells". Blood. 106 (13): 4114–4123. doi:10.1182/blood-2005-04-1450. PMID 16118314.
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–968. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Marteijn JA, van der Meer LT, van Emst L, van Reijmersdal S, Wissink W, de Witte T, et al. (November 2007). "Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1". Blood. 110 (9): 3128–3135. doi:10.1182/blood-2006-11-058602. PMID 17646546.
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