ARFIP1

Protein-coding gene in the species Homo sapiens
ARFIP1
Identifiers
AliasesARFIP1, HSU52521, ADP ribosylation factor interacting protein 1
External IDsOMIM: 605928; MGI: 1277120; HomoloGene: 8692; GeneCards: ARFIP1; OMA:ARFIP1 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for ARFIP1
Genomic location for ARFIP1
Band4q31.3Start152,779,937 bp[1]
End152,918,463 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for ARFIP1
Genomic location for ARFIP1
Band3|3 F1Start84,403,400 bp[2]
End84,489,932 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • epithelium of nasopharynx

  • visceral pleura

  • tibia

  • parietal pleura

  • mucosa of sigmoid colon

  • Achilles tendon

  • germinal epithelium

  • amniotic fluid

  • endometrium
Top expressed in
  • secondary oocyte

  • zygote

  • primary oocyte

  • granulocyte

  • jejunum

  • ileum

  • stomach

  • duodenum

  • ovary

  • placenta
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein domain specific binding
  • phosphatidylinositol-4-phosphate binding
  • phospholipid binding
Cellular component
  • cytosol
  • trans-Golgi network membrane
  • Golgi membrane
  • cytoplasm
Biological process
  • intracellular protein transport
  • regulation of Arp2/3 complex-mediated actin nucleation
  • regulation of protein secretion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27236

99889

Ensembl

ENSG00000164144

ENSMUSG00000074513

UniProt

P53367

G5E8V9

RefSeq (mRNA)
NM_001025593
NM_001025595
NM_001287431
NM_001287432
NM_001287433

NM_014447

NM_001081093
NM_001293801

RefSeq (protein)
NP_001020764
NP_001020766
NP_001274360
NP_001274361
NP_001274362

NP_055262

NP_001074562
NP_001280730

Location (UCSC)Chr 4: 152.78 – 152.92 MbChr 3: 84.4 – 84.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Arfaptin-1 is a protein that in humans is encoded by the ARFIP1 gene.[5][6][7]


Interactions

ARFIP1 has been shown to interact with ARF3.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164144 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074513 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Kanoh H, Williger BT, Exton JH (Apr 1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". J Biol Chem. 272 (9): 5421–9. doi:10.1074/jbc.272.9.5421. PMID 9038142.
  6. ^ a b Williger BT, Provost JJ, Ho WT, Milstine J, Exton JH (Aug 1999). "Arfaptin 1 forms a complex with ADP-ribosylation factor and inhibits phospholipase D". FEBS Lett. 454 (1–2): 85–9. doi:10.1016/S0014-5793(99)00771-1. PMID 10413101. S2CID 40655171.
  7. ^ "Entrez Gene: ARFIP1 ADP-ribosylation factor interacting protein 1 (arfaptin 1)".

Further reading

  • Tsai SC, Adamik R, Hong JX, et al. (1998). "Effects of arfaptin 1 on guanine nucleotide-dependent activation of phospholipase D and cholera toxin by ADP-ribosylation factor". J. Biol. Chem. 273 (33): 20697–701. doi:10.1074/jbc.273.33.20697. PMID 9694811.
  • Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ho WT, Exton JH, Williger BT (2003). "Arfaptin 1 inhibits ADP-ribosylation factor-dependent matrix metalloproteinase-9 secretion induced by phorbol ester in HT 1080 fibrosarcoma cells". FEBS Lett. 537 (1–3): 91–5. doi:10.1016/S0014-5793(03)00098-X. PMID 12606037. S2CID 44551128.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Foster LJ, Rudich A, Talior I, et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.


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