AKAP5

Protein-coding gene in the species Homo sapiens

AKAP5
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2H9R, 3LL8

Identifiers
AliasesAKAP5, AKAP75, AKAP79, H21, A-kinase anchoring protein 5
External IDsOMIM: 604688; MGI: 2685104; HomoloGene: 15854; GeneCards: AKAP5; OMA:AKAP5 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for AKAP5
Genomic location for AKAP5
Band14q23.3Start64,465,499 bp[1]
End64,474,503 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for AKAP5
Genomic location for AKAP5
Band12|12 C3Start76,371,665 bp[2]
End76,380,927 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • middle temporal gyrus

  • Brodmann area 23

  • entorhinal cortex

  • superior frontal gyrus

  • postcentral gyrus

  • nucleus accumbens

  • primary visual cortex

  • endothelial cell

  • caudate nucleus

  • prefrontal cortex
Top expressed in
  • left lung lobe

  • olfactory tubercle

  • nucleus accumbens

  • right lung

  • right lung lobe

  • lateral septal nucleus

  • globus pallidus

  • temporal lobe

  • Region I of hippocampus proper

  • amygdala
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein kinase A binding
  • calmodulin binding
  • protein binding
  • protein kinase A regulatory subunit binding
  • adenylate cyclase binding
  • SH3 domain binding
  • protein phosphatase 2B binding
  • beta-2 adrenergic receptor binding
  • molecular adaptor activity
  • glutamate receptor binding
  • GABA receptor binding
  • scaffold protein binding
Cellular component
  • cytosol
  • membrane
  • plasma membrane
  • cytoplasmic side of plasma membrane
  • postsynaptic density
  • dendrite membrane
  • dendritic spine
  • membrane raft
  • excitatory synapse
  • intracellular anatomical structure
Biological process
  • protein targeting
  • signal transduction
  • positive regulation of protein kinase A signaling
  • chemical synaptic transmission
  • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
  • negative regulation of adenylate cyclase activity
  • regulation of protein kinase A signaling
  • positive regulation of adenylate cyclase activity
  • positive regulation of protein localization to plasma membrane
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9495

238276

Ensembl

ENSG00000179841

ENSMUSG00000021057

UniProt

P24588
Q6PG46

D3YVF0

RefSeq (mRNA)

NM_004857

NM_001101471

RefSeq (protein)

NP_004848
NP_004848.3

NP_001094941

Location (UCSC)Chr 14: 64.47 – 64.47 MbChr 12: 76.37 – 76.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

A-kinase anchor protein 5 is a protein that in humans is encoded by the AKAP5 gene.[5][6][7]

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene is intronless and encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin 2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.[7]

Interactions

AKAP5 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000179841 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021057 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Carr DW, Stofko-Hahn RE, Fraser ID, Cone RD, Scott JD (Sep 1992). "Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79". J Biol Chem. 267 (24): 16816–23. doi:10.1016/S0021-9258(18)41856-X. PMID 1512224.
  6. ^ Carr DW, Hausken ZE, Fraser ID, Stofko-Hahn RE, Scott JD (Aug 1992). "Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain". J Biol Chem. 267 (19): 13376–82. doi:10.1016/S0021-9258(18)42221-1. PMID 1618839.
  7. ^ a b "Entrez Gene: AKAP5 A kinase (PRKA) anchor protein 5".
  8. ^ Kashishian A, Howard M, Loh C, Gallatin WM, Hoekstra MF, Lai Y (Oct 1998). "AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region". J. Biol. Chem. 273 (42): 27412–9. doi:10.1074/jbc.273.42.27412. PMID 9765270.
  9. ^ Brandon NJ, Jovanovic JN, Colledge M, Kittler JT, Brandon JM, Scott JD, Moss SJ (Jan 2003). "A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits". Mol. Cell. Neurosci. 22 (1): 87–97. doi:10.1016/s1044-7431(02)00017-9. PMID 12595241. S2CID 6172436.

Further reading

  • Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res. 52: 409–29, discussion 429–30. PMID 9238861.
  • Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol. 42: 235–57. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID 11807172.
  • Hirsch AH, Glantz SB, Li Y, et al. (1992). "Cloning and expression of an intron-less gene for AKAP 75, an anchor protein for the regulatory subunit of cAMP-dependent protein kinase II beta". J. Biol. Chem. 267 (4): 2131–4. doi:10.1016/S0021-9258(18)45852-8. PMID 1733921.
  • Carr DW, Stofko-Hahn RE, Fraser ID, et al. (1991). "Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif". J. Biol. Chem. 266 (22): 14188–92. doi:10.1016/S0021-9258(18)98665-5. PMID 1860836.
  • Coghlan VM, Perrino BA, Howard M, et al. (1995). "Association of protein kinase A and protein phosphatase 2B with a common anchoring protein". Science. 267 (5194): 108–11. Bibcode:1995Sci...267..108C. doi:10.1126/science.7528941. PMID 7528941.
  • Glantz SB, Li Y, Rubin CS (1993). "Characterization of distinct tethering and intracellular targeting domains in AKAP75, a protein that links cAMP-dependent protein kinase II beta to the cytoskeleton". J. Biol. Chem. 268 (17): 12796–804. doi:10.1016/S0021-9258(18)31458-3. PMID 8509414.
  • Faux MC, Scott JD (1997). "Regulation of the AKAP79-protein kinase C interaction by Ca2+/Calmodulin". J. Biol. Chem. 272 (27): 17038–44. doi:10.1074/jbc.272.27.17038. PMID 9202019.
  • Kashishian A, Howard M, Loh C, et al. (1998). "AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region". J. Biol. Chem. 273 (42): 27412–9. doi:10.1074/jbc.273.42.27412. PMID 9765270.
  • Paolillo M, Feliciello A, Porcellini A, et al. (1999). "The type and the localization of cAMP-dependent protein kinase regulate transmission of cAMP signals to the nucleus in cortical and cerebellar granule cells". J. Biol. Chem. 274 (10): 6546–52. doi:10.1074/jbc.274.10.6546. PMID 10037748.
  • Dodge KL, Carr DW, Sanborn BM (1999). "Protein kinase A anchoring to the myometrial plasma membrane is required for cyclic adenosine 3',5'-monophosphate regulation of phosphatidylinositide turnover". Endocrinology. 140 (11): 5165–70. doi:10.1210/endo.140.11.7133. PMID 10537145.
  • Fraser ID, Cong M, Kim J, et al. (2000). "Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling". Curr. Biol. 10 (7): 409–12. doi:10.1016/S0960-9822(00)00419-X. PMID 10753752.
  • Sík A, Gulácsi A, Lai Y, et al. (2000). "Localization of the A kinase anchoring protein AKAP79 in the human hippocampus". Eur. J. Neurosci. 12 (4): 1155–64. doi:10.1046/j.1460-9568.2000.00002.x. PMID 10762347. S2CID 40933732.
  • Colledge M, Dean RA, Scott GK, et al. (2000). "Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex". Neuron. 27 (1): 107–19. doi:10.1016/S0896-6273(00)00013-1. PMID 10939335.
  • Indolfi C, Stabile E, Coppola C, et al. (2001). "Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals". Circ. Res. 88 (3): 319–24. doi:10.1161/01.res.88.3.319. PMID 11179200.
  • Dart C, Leyland ML (2001). "Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1". J. Biol. Chem. 276 (23): 20499–505. doi:10.1074/jbc.M101425200. PMID 11287423.
  • Xie G, Raufman JP (2001). "Association of protein kinase A with AKAP150 facilitates pepsinogen secretion from gastric chief cells". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (4): G1051–8. doi:10.1152/ajpgi.2001.281.4.G1051. PMID 11557526. S2CID 20939022.


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