2-hydroxyglutarate synthase
2-hydroxyglutarate synthase | |||||||||
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Identifiers | |||||||||
EC no. | 2.3.3.11 | ||||||||
CAS no. | 9024-02-6 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 2-hydroxyglutarate synthase (EC 2.3.3.11) is an enzyme that catalyzes the chemical reaction
- propanoyl-CoA + H2O + glyoxylate 2-hydroxyglutarate + CoA
The 3 substrates of this enzyme are propanoyl-CoA, H2O, and glyoxylate, whereas its two products are 2-hydroxyglutarate and CoA.
This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming). Other names in common use include 2-hydroxyglutaratic synthetase, 2-hydroxyglutaric synthetase, alpha-hydroxyglutarate synthase, hydroxyglutarate synthase, and 2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating). This enzyme participates in c5-branched dibasic acid metabolism.
See also
- D2HGDH
- L2HGDH
- 2-hydroxyglutarate dehydrogenase
- 2-Hydroxyglutaric aciduria
- Hydroxyacid-oxoacid transhydrogenase
References
- Reeves HC, Ajl SJ (July 1962). "Alpha-hydroxyglutaric acid synthetase". Journal of Bacteriology. 84: 186–7. PMC 277798. PMID 14491016.
- v
- t
- e
- acetyltransferases: Acetyl-Coenzyme A acetyltransferase
- N-Acetylglutamate synthase
- Choline acetyltransferase
- Dihydrolipoyl transacetylase
- Acetyl-CoA C-acyltransferase
- Beta-galactoside transacetylase
- Chloramphenicol acetyltransferase
- N-acetyltransferase
- Histone acetyltransferase
- Citrate synthase
- Decylcitrate synthase
- Citrate (Re)-synthase
- Decylhomocitrate synthase
- 2-methylcitrate synthase
- 2-ethylmalate synthase
- 3-ethylmalate synthase
- ATP citrate lyase
- Malate synthase
- HMG-CoA synthase
- 2-hydroxyglutarate synthase
- 3-propylmalate synthase
- 2-isopropylmalate synthase
- Homocitrate synthase
- Sulfoacetaldehyde acetyltransferase